ISSN 2051-8315
Psychopathology Review
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 Volume 1, Issue 1, 157-168, 2014
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D-Cycloserine Augmented Treatment of Anxiety Disorders in Children and Adolescents: A Review of Preliminary Research

Authors
  Simon Byrne - Centre for Emotional Health, Department of Psychology, Macquarie University.
  Lara Farrell - School of Applied Psychology, Griffith Health Institute, Griffith University.
  Eric Storch - Department of Paediatrics, Rothman Centre for Neuropsychiatry, University of South Florida.
  Ronald Rapee - Centre for Emotional Health, Department of Psychology, Macquarie University.

Volume 1, Issue 1, 2014, Pages 157-168
DOI: http://dx.doi.org/10.5127/pr.033013

Abstract
This paper reviews evidence for using the "cognitive enhancer" D-Cycloserine (DCS) to treat anxious young people. Adult studies indicate DCS consolidates fear extinction learning into memory during exposure therapy, thereby increasing the speed of remission. This paper examines basic research indicating both fear extinction and DCS may work differently in younger animals compared to adults. It reviews trials using DCS to enhance treatment of obsessive compulsive disorder in youths. Given there is often ambivalence about using medication to treat young people, this paper also reviews current research examining parental attitudes to DCS. It considers specific challenges facing DCS research, particularly with regard to maintaining experimental control and managing negative perceptions associated with using medication. Finally, this paper considers current research underway, particularly with regard to using DCS to treat young people with specific phobias. Overall, findings indicate that DCS shows promise for enhancing the treatment of anxiety in young people, but further investigation is needed to determine whether it provides significant benefits over and above current therapies.

Table of Contents
Introduction
D-Cycloserine as a Cognitive Enhancer for Exposure Therapy
What Can Be Learnt From Adult D-Cycloserine Studies
Will D-Cycloserine Work in Children? Evidence from Fear Extinction in Younger Animals
D-Cycloserine Augmentation for Childhood Obsessive Compulsive Disorder
Will Parents Allow their Children to Take D-Cycloserine?
Issues when Conducting D-Cycloserine Research in Children: Maintaining Control Whilst Managing Perception
Current Trends and Future Directions
Conclusions
Acknowledgements
References

Correspondence to
Simon P. Byrne, Centre for Emotional Health, Department of Psychology, Faculty of Human Sciences, Building C3A, Macquarie University, North Ryde, 2109, Australia.

Keywords
Cognitive Enhancer, D-Cycloserine, Exposure Therapy, Anxiety, Specific Phobia, Obsessive Compulsive Disorder

Dates
Received 16 Sep 2013; Revised 16 Dec 2013; Accepted 12 Jan 2014; In Press 28 Jul 2014







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