| Volume 4, Issue 2, 169-188, 2015 |
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|Genetics in experimental psychopathology: From laboratory models to therapygenetics. Where do we go from here?|
| Tina Lonsdorf - Department of Systems Neuroscience, University Medical Center Hamburg-Eppendorf, Hamburg, Germany|
| Johanna Baas - Experimental Psychology and Helmholtz Institute. Faculty of Social Sciences, Utrecht University, Utrecht, Netherlands|
|Volume 4, Issue 2, 2015, Pages 169-188|
|Experimental psychopathology is the application of experimental methods to the study of psychopathology and its underlying processes. The study of individual differences in the development, maintenance and/or relapse of psychopathology is currently at the forefront of research. Stressful events are known to exert a substantial impact on our lives. Why however, do some people react in an extremely adaptive way, while others develop pathology in the aftermath of a trauma? One particularly interesting individual differences factor is genetic makeup and the aim of this paper is to review the current state of the art of genetics in experimental psychopathology which is illustrated by using fear conditioning as an exemplary model in the study of mechanisms underlying anxiety. We identify and discuss current challenges of the field and provide recommendations on how these can be met. In addition, criteria for experimental models of psychopathology as well as future directions are discussed. |
|Table of Contents|
The Candidate gene approach
Pitfalls and recommendations.
Definition of psychiatric (endo)phenotypes
Current definitions of psychiatric phenotypes.
Advances in neurobiology may inform novel definitions of phenotypes.
Fear conditioning as an exemplary model for genetics in experimental psychopathology
Fear conditioning, extinction and return of fear as laboratory models for the acquisition, treatment and the relapse of fear.
A prototypical model for the study of genetics in psychopathology.
Gene x environment interaction
Beyond single gene association studies
Generalization of the candidate gene approach: polygenic scores.
An outlook on the future
|Tina Lonsdorf |
| genetics, experimental psychopathology, fear conditioning, polymorphism, polygenic scores, recommendations |
|Received 18 Mar 2015; Revised 2 Jun 2015; Accepted 22 Jun 2015; In Press 1 Oct 2015 |